THIRD WORLD NETWORK BIOSAFETY INFORMATION SERVICE
Dear Friends and Colleagues
Safety Standards for Glyphosate-based Herbicides Deemed Outdated and Inadequate
A peer-reviewed article published in the Journal of Epidemiology & Community Healthreviews information on the use, exposures, mechanisms of action, toxicity and epidemiology of glyphosate-based herbicides (GBHs). It points out that most of the science used to support the safety standards for GBHs in the U.S. was carried out more than 30 years ago, and concludes that such standards areoutdated and may fail to protect public health and the environment from the full complement of health effects that could be induced by exposure to GBHs.Epidemiology studies suggest associations between GBH exposure and adverse health outcomes including chronic kidney disease and cancer.
Glyphosate is the No.1 weed-killer in the U.S., used extensively with herbicide-resistant GM crops, and also to speed up the natural drying of seeds before harvest. Residues of glyphosate and aminomethylphosphonic acid (AMPA, the major bioactive metabolite of glyphosate) have been routinely detected in soybeans, wheat, barley and many other crops and foods. GBHs are a mixture of glyphosate plus numerous other "inert ingredients". These chemical mixtures can be more toxic than glyphosate alone. The use of GBHs increased ∼100-fold from 1974 to 2014. Unfortunately, no systematic data tracked changes in glyphosate or AMPA concentrations in human tissues or bodily fluids during this period.
The authors call for: (a) improved biomonitoring of glyphosate and its metabolites in human populations; (b) hazard assessments using state-of-the-art technical approaches to be conducted on glyphosate and GBHs; (c) epidemiological studies examining occupationally exposed workers, pesticide manufacturers, and vulnerable populations and (d)evaluations of GBHs in commercially used formulations, recognising that herbicide mixtures likely have effects that are not predicted by studying glyphosate alone.
With best wishes,
Third World Network
131 Jalan Macalister
Websites: http://www.biosafety-info.net/and http://www.twn.my/
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IS IT TIME TO REASSESS CURRENT SAFETY STANDARDS FOR GLYPHOSATE-BASED HERBICIDES?
Vandenberg LN, Blumberg B, Antoniou MN et al.
Journal of Epidemiology and Community Health
Use of glyphosate-based herbicides (GBHs) increased ∼100-fold from 1974 to 2014. Additional increases are expected due to widespread emergence of glyphosate-resistant weeds, increased application of GBHs, and preharvest uses of GBHs as desiccants. Current safety assessments rely heavily on studies conducted over 30 years ago. We have considered information on GBH use, exposures, mechanisms of action, toxicity and epidemiology. Human exposures to glyphosate are rising, and a number of in vitro and in vivo studies challenge the basis for the current safety assessment of glyphosate and GBHs. We conclude that current safety standards for GBHs are outdated and may fail to protect public health or the environment. To improve safety standards, the following are urgently needed: (1) human biomonitoring for glyphosate and its metabolites; (2) prioritisation of glyphosate and GBHs for hazard assessments, including toxicological studies that use state-of-the-art approaches; (3) epidemiological studies, especially of occupationally exposed agricultural workers, pregnant women and their children and (4) evaluations of GBHs in commercially used formulations, recognising that herbicide mixtures likely have effects that are not predicted by studying glyphosate alone.
WEEDKILLER CHEMICAL (GLYPHOSATE) SAFETY STANDARDS NEED URGENT REVIEW
Emerging evidence suggests that the safety standards for glyphosate--a chemical widely used in common weed-killers--may be failing to protect public and environmental health, suggest experts in an essay published in the Journal of Epidemiology & Community Health.
The standards are based on out of date science, say the researchers, and may not therefore be able to address the full complement of potential health hazards associated with exposure to these chemicals. They call for an urgent review of these standards.
Earlier this month, the European Chemicals Agency gave glyphosate the all-clear, concluding that it is not linked to a heightened risk of cancer in people. This ruling will be used to inform the European Commission's decision later this year on whether to re-authorise the use of this chemical.*
In the US, glyphosate use has increased rapidly over the past two decades and it is now the most widely used weed-killer in the nation. And global estimates suggest that in 2014 enough glyphosate was used to spray nearly 0.5 kg on every hectare of arable land across the entire planet.
Glyphosate is not only used to kill off weeds before crops are planted, and to control weed growth afterwards, but it is also used to speed up the natural drying of seeds before harvest. Residues have also been found in soybeans, wheat, barley and many other crops and foods, say the researchers.
But most of the science used to support the safety standards applied in the US was carried out more than 30 years ago, and relatively little of it was subject to peer review, they point out. More than 1500 studies have been published on the chemical over the past decade alone.
"It is incongruous that safety assessments of the most widely used herbicide on the planet rely largely on fewer than 300 unpublished, non-peer reviewed studies while excluding the vast modern literature on glyphosate effects," say the experts.
And despite the rapid increase in use there is no systematic monitoring system for tracking levels in human tissue, and few studies have looked at potential harms to human health.
But recent animal studies have suggested that glyphosate at doses lower than those used to assess risk, may be linked to heightened risks of liver, kidney, eye and cardiovascular system damage.
And weed-killers, which combine glyphosate with other 'so-called inert ingredients,' may be even more potent. But these mixtures are regarded as commercially sensitive by the manufacturers and are therefore not available for public scrutiny, say the experts.
Debate continues to rage as to whether glyphosate is associated with a heightened risk of cancer or whether it has the potential to disrupt hormone function.
The researchers call for:
- improved surveillance of the levels of glyphosate and its metabolites in people
- the latest state of the art tests and technology to be applied to risk assessments of these chemicals and other combination weed-killers
- further research to track occupational exposures in agricultural workers, manufacturers, and other vulnerable groups, such as pregnant women and their children
- evaluations of commercial combination weed-killers containing glyphosate.
"After a review of all evaluations, we conclude that the current safety standards are outdated and may fail to protect public health and the environment," they write.