THIRD WORLD NETWORK BIOSAFETY INFORMATION SERVICE
Dear Friends and Colleagues
Cayman Government Cancels Nationwide Roll-out of GM Mosquito Programme
A series of emails between Mosquito Research and Control Unit (MRCU) officials of the Cayman Islands and British biotech firm Oxitec, released under the Freedom of Information Law, show the two parties were close to agreement on a two-year, US$8 million deal in August 2017 for a nationwide roll-out of a GM mosquito programme (Item 1). But the government has reportedly backed away from the arrangement, budgeting only CI$940,000 in 2018 for a much smaller-scale deployment of the technique in West Bay – essentially a rerun of the pilot deployment in that area from 2016 and 2017, funded largely by Oxitec. The correspondence suggests that the parties came to some form of draft agreement to continue the project in West Bay for this year only and to use other undefined mosquito fighting techniques (Item 2).
The decision to cancel the nationwide roll-out appears to have been driven by a mix of budget issues and concerns that more data are needed to assess the effectiveness of the method of suppressing local populations of the disease-spreading Aedes aegypti mosquito. According to a chain of correspondence between the MRCU, the ministry and Oxitec executives, not all of those involved in the project believed it was working or that the West Bay pilot was as successful as Oxitec had claimed.
Meanwhile, in Brazil, a lawsuit was filed by Oxitec against Anvisa, the country’s national health regulatory agency, which was reviewing a GM mosquito prior to its proposed commercial release in the country. Oxitec has released the GM mosquitoes at five sites in field trials, following approval by the National Technical Commission on Biosafety (CTNBio). In what may be seen as a setback for comprehensive biosafety oversight, the court agreed with Oxitec that Anvisa has no jurisdiction to regulate the mosquito, even though it is the agency under the Ministry of Health tasked to promote the protection of the population’s health by executing sanitary control of the production, marketing and use of products and services subject to health regulation.(See https://gauchazh.clicrbs.com.br/saude/noticia/2018/03/justica-autoriza-empresa-a-comercializar-aedes-aegypti-modificado-cjf4hcotv00nw01qbyoljef6k.html).
With best wishes,
GOVERNMENT BACKS AWAY FROM GENETICALLY MODIFIED MOSQUITO ROLLOUT
by James Whittaker
14 Feb 2018
A multimillion dollar plan for the islandwide rollout of Cayman’s genetically modified mosquito program has been significantly scaled back amid budget cuts and concerns that the technology has yet to fully prove itself.
A series of emails between Mosquito Research and Control Unit officials and British biotech firm Oxitec, released under the Freedom of Information Law, show the two parties were close to agreement on a two-year, US$8 million deal in August last year.
But government backed away from the arrangement, budgeting only CI$940,000 in 2018 for a much smaller-scale deployment of the technique in West Bay – essentially a rerun of the pilot deployment in that area from 2016 and 2017.
The decision appears to have been driven by a mix of budget issues and concerns that more data is needed to assess the effectiveness of the method of suppressing local populations of the disease-spreading Aedes aegypti mosquito.
There is no evidence of any safety or public health concerns on either side and the primary issue seems to be value for money. The total budget for the Mosquito Research and Control Unit for the next two years is CI$14.9 million.
The email exchanges reveal, for the first time, the likely costs of a large-scale deployment of genetically modified mosquitoes in the Cayman Islands. The initial pilot project in West Bay, which ended in August last year, was funded largely by Oxitec, though government made a US$200,000 contribution to extend it beyond the agreed deadline.
An Aug. 7 email from Richard Adey, Oxitec’s regional manager for the Caribbean, to Nancy Barnard, the acting director of Cayman’s Mosquito Research and Control Unit, suggests that a US$8 million plan had been agreed for a national rollout in 2018/19.
“Needless to say, we are delighted to be intensifying our work with the MRCU,” Mr. Adey wrote in that email.
A little over a month later, the picture appears to have changed completely.
In a letter to Jennifer Ahearn, the head civil servant in the ministry responsible for the MRCU, Mr. Adey expressed concern that the national rollout was not proceeding.
He said Oxitec was “surprised” that the decision to “expand our technique throughout Grand Cayman appears to have been revised.”
The letter goes on to express concern about the lack of clear messaging and “scientific rationale” for decisions coming from the MRCU since the departure of the former director of the unit, Bill Petrie, who left for a similar job in Miami in July 2017.
“This collaborative cooperation appears somewhat diminished and there is a lack of consistency and objectivity emerging,” Mr. Adey wrote.
“Our perception is that the positioning of our technology and its deployment in Grand Cayman appears to be changing, and the technical goalposts moved without good scientific rationale.”
Despite that impasse, the emails show that by the end of the year, the partners were close to agreement on a deal for a new project in West Bay only in 2018.
The emails also suggest some MRCU scientists had expressed concern about the effectiveness of the technology.
In exchanges between Mr. Adey and Ms. Barnard, both acknowledge that the GM mosquitoes have yet to meet “suppression targets,” though this is partly attributed to an unspecified “setback” unconnected to the efficacy of the technique.
Both acknowledge that the technology is showing “positive trends,” though the actual suppression data is redacted from the FOI response. There also appears to be some internal difference of opinion within the MRCU on whether there is enough data to justify further investment in GM mosquitoes.
Responding to questions from the Compass this week, Ms. Barnard acknowledged a draft agreement had been developed for the national rollout but said there was never a signed contract.
She said the MRCU and Oxitec were still in the process of developing a new program for West Bay in 2018, involving using GM mosquitoes in combination with other techniques.
She said the decision not to go ahead with a national rollout was “partially dictated by budget and partially to allow MRCU scientists to assess a new integrated vector management approach with Oxitec in the same area of West Bay as in 2018.”
She acknowledged there had been differences of opinion between government and its partner but said they worked closely together to resolve these issues.
The emails also show Oxitec chasing payment for extending the project in West Bay beyond the end of the contract in April 2017.
It was not clear from the messages if the issue had been resolved, but Ms. Barnard confirmed Oxitec would be paid US$200,000 for extending that pilot deployment through to August 2017.
It is understood that this is the only direct financial contribution government has made to the project so far.
Kerrie Cox, a lawyer who made the FOI request on behalf of his client, U.S. nonprofit Genewatch, said the emails showed the technology had been over hyped.
“Although the actual test results from the West Bay ‘pilot deployment’ of GMMs [genetically modified mosquitoes] have been redacted from the FOI disclosure, it is pretty clear that they did not achieve anything like the rates of Aedes aegypti suppression, that were repeatedly suggested as achievable, by former MRCU Director Bill Petrie ….
“For the first time, we now have an idea of the cost of a full deployment programme of GMMs in the Cayman Islands and, at this juncture, it is difficult to reconcile any notion that this project would represent value for money, if it were to proceed.”
SUCCESS OF GM MOZZIE PROJECT QUERIED BY MRCU
20 Feb 2018
(CNS): Government has cancelled a planned national roll-out of the controversial genetically modified mosquito project by the UK-based firm Oxitec. Nancy Barnard, the acting director of the Mosquito Research and Control Unit, told CNS that the decision not to expand the experimental method for suppressing the Aedes aegypti was due to budget cuts. However, it appears that government was questioning the success of the entire project, with divisions between the former head of the MRCU and his senior staff over the impact of releasing the bio-engineered insect.
According to a chain of correspondence between the MRCU, the ministry and Oxitec executives, not all of those involved in the project believed it was working or that the West Bay pilot was as successful as Oxitec had claimed.
Earlier this month CNS submitted questions to the MRCU about the situation regarding the current mosquito project. On Friday, Barnard responded and told us that there would not be a national roll-out, largely due to government-wide budgeting considerations.
“MRCU and Oxitec are now looking into an integrated programme using all methods available to fight Aedes aegypti in full synergy,” she said. “The 2018 programme will allow MRCU scientists time to assess a fully integrated vector management (IVM) approach with Oxitec in West Bay. MRCU is in the final stages of talks with Oxitec regarding the ‘Friendly Aedes aegypti Programme’ for 2018.”
But last week, as a result of an FOI request, the MRCU released a long chain of correspondence between the unit, government officials and Oxitec executives covering the life of the project. It is clear from the email chains that not everyone at MRCU or the ministry was convinced the GM mosquitoes were having a significant impact, and concerns were raised about the failure to reach the sustained suppression rates that had been expected.
Oxitec blamed the lower rates on the delays it experienced getting a further licence to import the eggs after the National Conservation Council requested an environmental assessment, but the MRCU appeared to believe that this setback was not the only reason for the lower than expected suppression rates.
It seemed that while the former MRCU director, Dr Bill Petrie, had recommended the national roll-out, other scientists at the department had concerns about how successful the West Bay pilot had been. Following Petrie’s departure from the unit last summer and after mixed messages from government to their private sector partners, the planned island-wide roll out was shelved by the ministry and the MRCU.
By the end of September last year, it was clear that no money was going to be allocated in the two-year 2018/19 budget for the island-wide roll-out of the genetically modified mosquitoes. Oxitec then began accusing government officials of having a lack of “scientific rationale” behind the decision-making after Dr Petrie resigned, as well as a lack of consistency and objectivity.
The correspondence suggests that the parties came to some form of draft agreement to continue the project in West Bay for this year only and to use other undefined mosquito fighting techniques.
It is not clear if the MRCU will be turning to other bio-engineering techniques now available, as the correspondence ends with the departure of Oxitec’s Caribbean consultant, Richard Adey, who was dealing with the Cayman contract but became a casualty of cost-cutting measures by Intrexon, Oxitec’s parent company.