Bt Toxins in GE Plants Can Be Much Higher Than Previously Known

THIRD WORLD NETWORK BIOSAFETY INFORMATION SERVICE

 

Dear Friends and Colleagues

Bt Toxins in GE Plants Can Be Much Higher Than Previously Known

Data from Monsanto in 1990 reveal that Bt toxins expressed in GE plants are significantly more toxic than natural Bt toxins. This information was brought to light by Testbiotech (Institute for Independent Impact Assessment of Biotechnology), which recently came across the Monsanto publication.

Plants, such as soybean, cotton and maize, naturally produce enzymes known as protease inhibitors (PI); these prevent proteins from degradation. Even in small quantities PIs can cause the toxicity of Bt toxins to be as much as 20 times higher. The mechanism by which PIs potentiate the toxicity of Bt proteins might be a delay in the degradation of Bt toxins. Most of the existing evidence is concerning insects. However, there are also findings that the Bt toxins as produced by GE plants can persist much longer in the gut of mammals than previously expected.

Consequently, the toxicity and immunogenicity of Bt proteins produced in plants, such as maize, cotton and soybean, should be assumed to be much higher than compared to the naturally occurring Bt toxins. These problems relate to all Bt plants and they are especially relevant to so-called stacked events, which produce several Bt proteins and may thus contain higher overall concentrations of the toxins. However, these effects have thus far not been investigated in relation to the risks to health and the environment.

 

With best wishes,

Third World Network
131 Jalan Macalister
10400 Penang
Malaysia
Email: twn@twnetwork.org
Websites: http://www.twn.my/and http://www.biosafety-info.net/
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ARE GE PLANTS WITH BT TOXINS 20 TIMES MORE TOXIC THAN PREVIOUSLY KNOWN?

Testbiotech
11 December 2020
https://www.testbiotech.org/en/press-release/are-ge-plants-bt-toxins-20-times-more-toxic-previously-known

EFSA has for decades ignored crucial data from Monsanto

Data from Monsanto revealed that Bt proteins expressed in genetically engineered (GE) plants are significantly more toxic than natural Bt toxins. It is more than 30 years ago since, in 1990, Monsanto data first showed that if mixed with plant material from, e.g. soybeans, cotton and maize, toxicity could be up to 20 times higher. This is due to enzymes naturally present in the tissues of many crop plants. These findings were never taken into account by the European Food Safety Authority (EFSA). It seems as if EFSA simply overlooked the relevant publications. EFSA routinely accepts tests with isolated Bt proteins produced by bacteria to assess the risks of GE plants.

Testbiotech became aware of this 30-year old Monsanto publication whilst assessing new applications for import approval of GE plants. Testbiotech has also become aware of several more recent publications confirming the original Monsanto findings.

Bt proteins, which are naturally produced by soil bacteria, were introduced into GE plants to make them toxic to specific insects. At the same time, plants, such as soybean, cotton and maize, also naturally produce enzymes known as protease inhibitors (PI); these prevent proteins from degradation. Even in small quantities PIs can cause the toxicity of Bt toxins to be as much as 20 times higher; this has thus far been completely ignored in risk assessment. The mechanism by which PIs potentiate the toxicity of Bt proteins might be a delay in the degradation of Bt toxins. Most of the existing evidence is concerning insects. However there are also findings that the Bt toxins as produced by GE plants can persist much longer in the gut of mammals than previously expected.

Consequently, the toxicity and immunogenicity of Bt proteins produced in plants, such as maize, cotton and soybean, has to be assumed to be much higher compared to the naturally occurring Bt toxins. These problems relate to all Bt plants approved for import or cultivation in the EU and mixtures in food and feed. They are especially relevant to so-called stacked events which produce several Bt proteins and may thus contain higher overall concentrations of the toxins. However, neither EFSA nor industry have ever mentioned or investigated the risks to health and the environment associated with these effects. For example, EFSA has never requested empirical data on the overall toxicity of stacked events expressing up to six Bt proteins in parallel.

Several new applications for GE plants for import might soon be approved. Five new applications have been filed for maize and soybeans that express Bt toxins and / or are resistant to herbicides. The companies involved are Bayer (Monsanto) and Syngenta.

Resolutions against the new approvals have already been adopted by the Committee on Environment of the EU Parliament. The EU Parliament is expected to take a final vote on the applications in mid-December in a plenary sitting. These votes are not binding for the EU Commission. However, according to Testbiotech, the renewed strong evidence for huge gaps in EFSA risk assessment cannot be ignored in the upcoming decision-making. Therefore, Testbiotech demands that the current approval processes are stopped and the current approval process is substantially revised.

Contact:

Christoph Then, info@testbiotech.org, Tel + 49 (0) 151 54638040

Further information:

The Monsanto publication: https://pubs.acs.org/doi/10.1021/jf00094a051
Recent information on the pending approval processes: www.testbiotech.org/en/news/eu-close-approving-new-ge-plants

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