CRISPR/Cas genome editing in mice can lead to unintentional epigenomic changes post modification, with generational persistence. […]
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We are pleased to share the Spanish, French and Portuguese translations of the new TWN/GeneWatch UK Biosafety Briefing, which sets out to show that currently deployed genome editing technologies and applications, including all techniques involving CRISPR-based systems, clearly fall within the Cartagena Protocol on Bisoafety’s definition of a living modified organism (LMO), whether they involve inserting, deleting or editing sequences of genomes. […] Without strict regulation of ‘New Genetic Engineering’ techniques, there will be substantial likelihood of damage to ecosystems, agriculture, forestry and food production. […] The first-ever detection method for a commercialised GM rapeseed/canola developed with gene editing has been published and is now open source, allowing regulators, food companies, retailers, certification bodies and national food safety inspectors to detect this gene edited crop. […] A new scientific paper reveals that genome editing can cause genomic irregularities in the resultant GMOs, even if genes are not inserted, or inserted only transiently. This underscores the need for a process-oriented risk assessment, which would also improve the risk assessment of first-generation GMOs. […] A new wave of second-generation GE strategies are being used to push risky biotechnological solutions to malaria and locust infestations in Africa, diverting attention and investment away from more effective sovereign systemic solutions to overcome ecological, economic and health crises. […] CRISPR gene editing in rice varieties caused undesirable and unintended on-target and off-target mutations, according to a recent study. […] Research has found that the standard gene-editing tool, CRISPR-Cas9, frequently produces a type of DNA mutation that ordinary genetic analysis misses, suggesting that gene-editing is more error-prone than previously thought. […] To control the risks of gene drives, ‘cut-off criteria’ need to be defined to prevent the uncontrolled spread of genetically engineered gene drive organisms. […] A report endorsed by eight European environmental agencies has been published on the implications on the environment and nature conservation of gene drive organisms. […] |
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