CRISPR gene editing in rice varieties caused undesirable and unintended on-target and off-target mutations, according to a recent study. […]
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Research has found that the standard gene-editing tool, CRISPR-Cas9, frequently produces a type of DNA mutation that ordinary genetic analysis misses, suggesting that gene-editing is more error-prone than previously thought. […] To control the risks of gene drives, ‘cut-off criteria’ need to be defined to prevent the uncontrolled spread of genetically engineered gene drive organisms. […] A report endorsed by eight European environmental agencies has been published on the implications on the environment and nature conservation of gene drive organisms. […] US FDA scientists report that the gene editing process to produce hornless cattle resulted in unintended alterations at a genome-edited target site, and say this is a reason why regulatory oversight of intentional genomic alterations in animals is needed. […] A study has found that CRISPR-Cas9 edits intended to knock out the function of a gene fail to do so. Functional proteins are still produced from the damaged genes, which can result in the production of gene-edited plants that are toxic or allergenic. […] The European Parliament has passed a resolution calling on the European Commission and Member States to call for a global moratorium on gene drive releases into nature, including field trials. […] A new complex technique called ‘prime editing’ is touted to be far more precise than the CRISPR gene-editing tool, but in all likelihood, the same undesirable off-target and on-target effects will occur. […] New technologies allow nucleic acids and proteins to be delivered to cells, tissues and organisms in the open environment. However, the current lack of regulatory oversight could lead to either dual use appropriation or unintended harm to human health or the environment. […] Gene drives proposed for conservation purposes pose serious threats because their implementation could have far-reaching unintended consequences and could trigger irremediable modification of the natural environment. […] |
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