THIRD WORLD NETWORK BIOSAFETY INFORMATION SERVICE
Dear Friends and Colleagues
Study Finds Roundup Causes Harm to Daphnia, Demonstrating Risks to Wildlife
Research around the weedkiller Roundup, the world’s most ubiquitous herbicide that is also used with many GM herbicide-resistant crops, is among the most contentious of the twenty-first century. Much of this controversy is rooted in outdated toxicity tests, which only look at the number of animals that die on exposure to extremely high concentrations of chemicals and overlook the pathological effects arising from long-term exposure to low doses.
A new study applied a systems biology approach using Daphnia (waterfleas) to quantify the impact of glyphosate and its commercial formula, Roundup, on fitness, genome-wide transcription and gut microbiota. The study found that prolonged exposure to environmentally relevant concentrations of Roundup caused significant harm to Daphnia, a keystone species. The researchers found that even at approved regulatory levels, the weedkiller caused embryonic development failure and significant DNA damage, and interfered with the animals’ metabolism and gut function.
These findings are important since Daphnia are at the heart of aquatic food webs. The ‘systems biology’ approach employed in this study enables toxicity to be measured by what happens to the animal at a molecular and fitness level following long-term exposure, which encompasses the entire animal life cycle. By using similarity in molecular functions across species, the researchers can also track these effects across different species, including the potential effects of herbicides on humans.
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Item 1
ROUNDUP CAUSES EMBRYONIC DEVELOPMENT FAILURE AND ALTERS METABOLIC PATHWAYS AND GUT MICROBIOTA FUNCTIONALITY IN NON-TARGET SPECIES
Suppa, A., Kvist, J., Li, X. et al.
Microbiome Volume 8, Article number: 170 (2020)
15 Dec 2020
https://doi.org/10.1186/s40168-020-00943-5
https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00943-5
Abstract
Background
Research around the weedkiller Roundup is among the most contentious of the twenty-first century. Scientists have provided inconclusive evidence that the weedkiller causes cancer and other life-threatening diseases, while industry-paid research reports that the weedkiller has no adverse effect on humans or animals. Much of the controversial evidence on Roundup is rooted in the approach used to determine safe use of chemicals, defined by outdated toxicity tests. We apply a system biology approach to the biomedical and ecological model species Daphnia to quantify the impact of glyphosate and of its commercial formula, Roundup, on fitness, genome-wide transcription and gut microbiota, taking full advantage of clonal reproduction in Daphnia. We then apply machine learning-based statistical analysis to identify and prioritize correlations between genome-wide transcriptional and microbiota changes.
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Item 2
NEW RESEARCH HIGHLIGHTS IMPACTS OF WEEDKILLER ON WILDLIFE
University of Birmingham
16 Dec 2020
https://www.birmingham.ac.uk/news/latest/2020/12/new-research-highlights-impacts-of-weedkiller-on-wildlife.aspx
Prolonged exposure to environmentally relevant concentrations of the weedkiller Roundup causes significant harm to keystone species according to new research at the University of Birmingham.
A team in the University’s School of Biosciences used waterfleas, or Daphnia, to test the effects prolonged exposure to concentrations of Roundup deemed safe by regulatory agencies.
They found that even at approved regulatory levels, the weedkiller causes embryonic development failure, significant DNA damage, and also interferes with the animals’ metabolism and gut function.
These findings are important since Daphnia are at the heart of aquatic food webs. They can be used to assess the impacts of environmental changes on ecosystems. The results also offer a starting point for tracking these effects across different species, including the potential effects of herbicides on humans.
Lead researcher, Dr Luisa Orsini, says: “Research surrounding Roundup has been controversial since it first appeared on the market in the 1970s. Claims that it causes diseases and disorders ranging from cancer to autism stack up against industry-paid reports arguing that the product has no untoward effects.
“The problem is that much of the evidence is rooted in outdated toxicity tests which only look at the number of animals that die on exposure to extremely high concentrations of these chemicals. These tests also overlook the pathological effects arising from long-term exposure to low doses.
“What we’re proposing is that toxicity is measured by looking at what happens to the animal at a molecular and fitness level following long-term exposure, which encompasses the entire animal life cycle.”
This ‘systems biology’ approach will enable researchers to understand the changes caused by these chemicals on fundamental functions, such as the ability to metabolize sugars or to repair wound tissue. By using similarity in molecular functions across species, the researchers can also infer the implications of these chemicals on humans.
The approach tested by the researchers can be applied to a wide number of chemicals in the environment. As well as herbicides, the team is applying their methods to investigate insecticides, anti-inflammatory drugs, antibiotics and heavy metals (arsenic), commonly found in contaminated water supplies around the world.
The team is working with the UK Environment Agency to bring new methods to regulatory agencies to screen for chemicals and their effect on biodiversity. Scientists and the Environment Agency have a long-term goal of modernizing environmental practice to more effectively regulate the use of chemicals and mitigate their impact on humans and the environment.
“Using our methods it will be possible to identify and rank the most harmful chemicals that are getting into the environment,” says Dr Orsini. “We can’t stop environmental contamination in one step, but by identifying the worst offenders, we can work with industrial partners in a more targeted and effective way.